After suffering defeat against PSV in the Champions League, the Red Devils will hope to get back to winning ways when they face Southampton in the Premier League.
Manchester United captain Wayne Rooney missed the last two games for the club because of slight hamstring injury.
The England international could return for the Red Devils against Southampton on Sunday but it remains to be seen whether he will be in the starting XI or not.
If the former Everton star does start, he will probably play behind marquee summer signing Anthony Martial. Rooney has not scored in his last 10 Premier League games and it makes complete sense to start him in the No. 10 position.
Louis van Gaal will have to change his starting back line for the first time this season in the absence of Luke Shaw. Expect Marcos Rojo to start in the left back position. Here is Man United’s probable XI vs the Saints.
Follow Soccerisma on Twitter: Soccerisma